Rest of the Story on Gene Editing

Many years ago there was a well-known radio news personality named Paul Harvey. He made a career out of digging into details on stories that were not publicized by the media. He called the reporting “The Rest of the Story.” People close to Harvey said that he got some heat from media people who felt he had made them look bad by revealing details they missed. With the general public, however, he was very popular. We want to examine the rest of the story on gene editing.

There has been a great deal of media reporting about CRISPR-Cas9 which is a tool for editing DNA introduced in 2012. Researchers hope that science can treat a wide range of genetic diseases by altering human DNA. The problem is that our understanding in this area is very primitive. Bioethicists writing in the Wall Street Journal (December 15, 2018, page C3) report, “scientists have only begun to understand what the tens of thousands of individual genes do. Moreover, they are far from unraveling how those genes interact with each other.”

When researchers deleted a gene that limits muscle growth in rabbits, the rabbits had enlarged tongues. Doing the same thing with pigs produced additional vertebrae. In calves the change caused the calves to die prematurely. Lambs grew too large in the womb to be born naturally. Lisa Moses who is a bioethicist at Harvard says, “Humans have a long history of messing around in nature with all kinds of unintended consequences. It’s really hubris of us to assume that we know what we are doing and that we can predict what kinds of bad things can happen.”

There are lessons to learn here. CRISPR has the potential to correct damage to DNA caused by human carelessness, pollution, and mismanagement. The rest of the story on gene editing is still to be written. When a Chinese scientist claims to have produced the first gene-edited human babies, there has to be immediate condemnation by the scientific community. Over the years, outstanding scientists have pointed out that science lacks the capacity to determine the use of its discoveries.

We desperately need Christians who are capable scientists using their faith in God to determine those uses. Will CRISPR be used to eliminate genetic diseases, or will it be used by political demagogues to produce pathogens that kill millions of innocent people? The Nobel Peace Prize was started by a man who discovered dynamite and was appalled at the way it was being used to fight wars. That kind of sensitivity is needed in today’s genetic research to write the rest of the story on gene editing.

Another lesson in all of this is that the complexity of the genetic code of life cannot be the result of chance – a blind watchmaker as some have suggested. Wisdom calls out in Proverbs 8, “O you simple ones, understand wisdom … for wisdom is better than rubies; and all things that may be desired are not to be compared to it. I wisdom dwell with prudence and find out knowledge of witty inventions … The Lord possessed me in the beginning of His way, before His works of old … Hear instruction and be wise and refuse it not.”
–John N. Clayton © 2019