Snakebite Antivenom and AI

For most of us living in the United States, it is hard to believe that around 100,000 people worldwide die from snakebites every year. Venomous snakes have a blizzard of toxins in their bite, but the most dangerous are the “three-finger toxins,” proteins that can stop a person’s heart and ability to breathe. Snakebite antivenom is produced today by milking snakes to extract their venom.

Technicians inject a small dose of venom into a horse or other large animal and harvest antibodies later to make snakebite antivenom. When medical personnel inject the antibodies into a snakebite victim, they bind to venom toxins, shutting them down. This process is expensive and time-consuming, so researchers want to find a better answer. The 2024 Nobel Prize in chemistry went to three chemists who used artificial intelligence (AI) to design proteins that can dampen and neutralize snake venom.

People have asked us, “Why would God create snakes with venom?” It is essential to understand that snakes control the populations of rats, mice, and other disease-carrying animals. What would happen if there was no predator to eat rodents when they go underground? Rodents above ground are preyed on by foxes, bears, hawks, and eagles and killed by humans. When they retreat underground, they are safe from all of those, but snakes can go after and kill rodents even there.

When a venomous snake bites a human, it is usually because the human has invaded the snake’s territory and deliberately confronted it. I was hiking into geologically interesting areas in a National Science Foundation workshop in Montana many years ago. As we walked down an old wagon trail, I was in the back with 20 people in front of me. Looking ahead, I saw a diamondback rattlesnake coiled and sitting in the middle of the wagon tracks. It had made no effort to strike any of the people within inches of it, relying totally on its camouflage.

Snakebite antivenom is essential to protect human lives, but non-venomous animals can also cause human deaths. The late Steve Irwin showed many beautiful snakes in his TV show. When he died at age 44 on September 4, 2006, it was not from a snake bite. A ray’s barb on Batt Reef in Australia pierced his heart, causing him to bleed to death. Unlike snakes, rays are not considered to be dangerous animals, but nobody has challenged us on why God created rays.

— John N. Clayton © 2025

Reference: Science News magazine for February 2025, pages 14-15 or sciencenews.org.