Tag: genetics

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Genes and Addiction

Genes and Addiction Ozzy OsbourneSince the first sequencing of the human genome in 2003, there have been exhaustive studies of links between the human gene structure and addiction. Discover Magazine published a report on genes and addiction (November 2019 issue) with a summary of the current findings.

The magazine focuses on Ozzy Osbourne, the singer/songwriter and reality TV star who is sometimes called “The Godfather of Heavy Metal.” He is famous for going on binges of alcohol, Vicodin, cocaine, and other drugs that would kill most humans. He has survived to be 70 years old. The question is why Osbourne was able to survive all of this abuse for such a long time. One major factor seems to be a mutation in the ADH4 gene. The ADH4 makes a protein called alcohol dehydrogenase 4, which breaks down alcohol. The researchers have concluded that Osbourne is six times more likely to have an alcohol dependency than the average person because alcohol has a minimal effect on him.

The question arises of what are the links between genes and addiction to alcohol and other substances. The Food and Drug Administration says that one in every 12 adults in the United States suffers from alcohol abuse or dependence. Americans spend $200 million a day on alcohol, and 100,000 people die each year from accidents linked to alcohol. People of East Asian descent have an increase in heart rate when consuming alcohol. That effect is called “Asian Flush” or “alcohol flush reaction.” Researches have also found genetic links to anandamide, which is a brain chemical that affects mood and anxiety. Marijuana doesn’t affect people with mutations that alter the amount of anandamide in the brain.

This newfound information tells us a lot about how mutations have shaped how we behave in our consumption of different chemicals. Obviously, if a person doesn’t consume the chemical, the mutations are not an issue. For some people, this information enables them to justify blaming God for their addiction. There are drugs like disulfiram, which cause people to have an unpleasant reaction to the consumption of alcohol. However, using a drug to counteract a destructive drug is a poor solution to the overall problem.

The mutations that have caused all of this are man-made. The mutations are linked to a variety of human enterprises, including the distillation of alcohol. In the distant past, addition was not much of an issue, because the chemical effect of undistilled alcohol is minimal. Alcohol is a drug, and it needs to be identified as such. God has not caused the mutations, and humans are responsible for virtually all of the drugs that are causing so much pain and destruction.

So there is a connection between genes and addiction, and science is looking for ways to change the human genome to exclude the mutations. The biblical solution is to form a relationship with God that leads us away from the destructive forces around us. At the same time, we need to reach out to those who are struggling with their addictions and help them find a way out of their lifestyle of abuse. Walking in the light (1 John 1) involves a conscious change that leads to a new life (Romans 6). God did not lead us to destructive lifestyles, but He will help us build a newness in our lives if we are willing to turn things over to Him.
— John N. Clayton © 2019

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Beauty of Earth’s Diversity

Beauty of Earths DiversityThe plant in the picture is called the “bird of paradise.” It is neither a bird, nor is it found in paradise. However, it is indeed a beautiful example of the beauty of Earth’s diversity in the plant world. One of the primary reasons many of us enjoy travel and visiting museums, zoos, and arboretums is that we are enthralled with the incredible diversity of living things.

We want to suggest that this diversity is more than a device to entertain us humans. From a scientific standpoint, it is the diversity of life on Earth that has led to the high standard of living available to us on this planet. As geneticists unravel the genome of living things, it becomes more and more apparent why agricultural breeding practices of the past have been successful. The production of super chickens, super cows, low-fat pork, and all the other unique breeds has been possible because of all the different genetic options God built into life. If, for example, there had been only one set of genes for all bovines on this planet, such cattle as the Charolais would not have been possible. It is only because we have an infinite number of genetic possibilities to draw from that we can select those that will serve our particular needs.

In plants, this is equally obvious. We have only begun to appreciate all that plants can do. Scientists have studied only a small percentage of all plants on this planet to see how we can use them. Cures for cancer, AIDS, the common cold, and a variety of other ailments may well be in a plant we have not yet investigated. It is self-evident in today’s world that solving the problem of hunger lies in the fuller use of plants. The diversity of plants holds the key to better nutrition, more and better fabrics to protect and shelter us, and even the improvement of air quality.

In God’s creative wisdom, He gave us a wide diversity of life of all kinds and told us to “take care of the Garden, dress it, and keep it” (Genesis 2:15). The future has vast potential for good if we will use in a constructive way all that God has given us. To arbitrarily destroy any of this diversity and thus end its potential usefulness is not only poor management of the “Garden,” but also the worst kind of foolishness.

We also suggest that the beauty of Earth’s diversity of humans offers the potential for vast good. Each of us has a gift designed into our makeup that uniquely qualifies us to bring great blessings to others. Paul said it best:

“According to the grace given to us, we have different gifts: If prophecy, use it according to the proportion of one’s faith; if service, use it in service, if teaching, in teaching; if exhorting, in exhortation; giving, with generosity; leading, with diligence; showing mercy, with cheerfulness” (Romans 12:6-8). See also 1 Corinthians 12:8-27.
— John N. Clayton © 2019

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Digital to Biological Converter

Digital to Biological Converter
The speed of scientific advancement in genetics and the use of computers in biochemistry is astounding. Scientists mapped the human genome in 2001. In May of 2018, Synthetic Genomics announced that they had created a working Digital to Biological Converter (DBC). The DBC turns digitized DNA code into synthetic biological material such as proteins. The process is called “Gibson Assembly” and can produce small pieces of DNA code called oligonucleotides and stitch the pieces together into DNA strands.

The exciting part of this new technology is that it could allow doctors to personalize medications to the individual needs of patients. Oncologists could create a medicine specifically targeted to the patient’s tumor. It has the potential to create vaccines to fight an epidemic quickly. The prototype machine is too large and too inefficient to be practical, but Synthetic Genomics hopes to have it available to medical researchers in three to five years.

Many of the health problems we have today whether genetic or otherwise have been caused by what we have done to ourselves and our environment with various chemicals and carcinogens. Some might say that we are “playing God” by creating synthetic genetic material. But if we have a way to correct the damage that our ancestors and we have done and relieve pain and suffering, we should certainly do it. The complexity of the Digital to Biological Converter and the material that it produces tells us more of God’s wisdom in the original construction of life.
–John N. Clayton © 2018

Reference: Wall Street Journal. July 14-15, 2018, page B4

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Human History in DNA

Human History in DNA
In the last decade, geneticists have learned how to decode DNA in ancient human remains. We can now begin to see human history in DNA. The media has saturated us with the theory that humans originated in Africa and migrated from there to the rest of the world. National Geographic was a major promoter of that theory, and it was based on the field work of a group of anthropologists like Louis Leakey who actively defended that view. Discussions about race have also been a part of this debate among scientists, and sometimes the exchanges have been less than cordial.

The most recent debate along these lines has come with the release of a book titled Who We Are and How We Got Here: Ancient DNA and the New Science of the Human Past by David Reich. Reich runs a lab at Harvard Medical School which has released a great deal of data in the past decade. In 2010 Reich’s lab informed us that all non-Africans have Neanderthal DNA in their genome. Reich maintains that race is a social construct and that differences in genetic makeup are geographically related.

A group of 67 scholars released an open letter on BuzzFeed.com objecting to Reich’s racial concepts. Other anthropologists have contended that the reality of our origins “is more complex and interesting than scientists ever imagined.”

The biblical description of human history is so brief that one should not look for conflicts with the biblical account. The Bible tells us that we are all related, and the fact that all races are fertile with one another supports that. The Bible does not tell us when Adam and Eve lived or how much time elapsed as humans migrated throughout the world.

A careful study of the Bible indicates that we are all equal and have a common ancestry. God’s design of our genome has allowed us to survive as a species for a very long time in spite of disease. Reich’s book supports that notion but gives us some idea of how the design has worked by examining human history in DNA.
–John N. Clayton © 2018

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Evolution in Action: The Incredible Goldfish

Bubble Eye Goldfish
Bubble Eye Goldfish

In Ocean Park in Hong Kong there is a “Goldfish House” which features some 300 different varieties of fish that appear to be creatures from another world. The Red Bubble Eye, for example, has two cheeks that bulge out like huge balloons with a yellow color bridging off from an orange body. The tricolor Dorsal-Finned Bubble Eye looks similar, but it has a large dorsal fin and its body is black and white and it has a long flowing black and white tail. The tricolor Ranchu has a face like a bulldog and a multicolored body and the Black Dragon Eye has two huge eyes that protrude from the body and large, delicate fins. All of these fish that look so different from one another descended from the Prussian carp, also known as Gibel carp, which were raised by Chinese Buddhists in the Tang Dynasty. By the tenth-century these fish which we call “goldfish” were prized as pets.

The Japanese took many of these very different kinds of goldfish back to Japan where raising unusual looking fish became a hobby of many people. By 1850 breeding clubs were formed in the United States and in Great Britain, there is a Goldfish Society with a large number of members. Goldfish have two sets of chromosomes from each parent, which means that mutations are preserved and expressed in many ways. Over 300 varieties exist at the present time.

Our local breeder of goldfish calls this “evolution at its best.” There are practical uses for this hobby. Most of these fish are small–four to ten inches–but there are varieties that grow to 25 pounds. I can remember crappie fishing in the 1960’s with goldfish minnows, which were raised by a fish farm in Martinsville, Indiana. They were effective as bait because of their visibility, but the rapid growth of these fish makes them ideal as a food source in some areas of the world.

Evolution is not a synonym for “man from monkey.” Evolution is a tool for producing new varieties of life which can benefit us in many ways. In the case of the goldfish there is aesthetic value in these changes, but also economic and nutritional value. When young people study biology in high school, they learn about how these genetic processes work and why. The design of the genetic materials that allow all of this is incredibly complex. In the Bible, Jacob used evolutionary change. The flocks of Laban were modified in a beneficial way by Jacob using these same principles. (See Genesis 30.)

All of the goldfish in the world are from the one species. It takes a creative imagination to visualize how some of these strange looking varieties of fish can form, but the changes do not involve adding organs or making massive changes in biological digestive processes.

God is the author of this process, and trying to understand how all of this was designed and how it came to be applied to all the life forms that exist on the earth today is an enthralling field of study for young biology students. Everywhere we look in the natural world we find that a wonder-working hand has gone before. Changes like those shown in the goldfish speak eloquently about how beautiful and creative the genetic design of life can be.
–John N. Clayton © 2017