Tag: CRISPR

Posted on

Rest of the Story on Gene Editing

Rest of the Story on Gene Editing
Many years ago there was a well-known radio news personality named Paul Harvey. He made a career out of digging into details on stories that were not publicized by the media. He called the reporting “The Rest of the Story.” People close to Harvey said that he got some heat from media people who felt he had made them look bad by revealing details they missed. With the general public, however, he was very popular. We want to examine the rest of the story on gene editing.

There has been a great deal of media reporting about CRISPR-Cas9 which is a tool for editing DNA introduced in 2012. Researchers hope that science can treat a wide range of genetic diseases by altering human DNA. The problem is that our understanding in this area is very primitive. Bioethicists writing in the Wall Street Journal (December 15, 2018, page C3) report, “scientists have only begun to understand what the tens of thousands of individual genes do. Moreover, they are far from unraveling how those genes interact with each other.”

When researchers deleted a gene that limits muscle growth in rabbits, the rabbits had enlarged tongues. Doing the same thing with pigs produced additional vertebrae. In calves the change caused the calves to die prematurely. Lambs grew too large in the womb to be born naturally. Lisa Moses who is a bioethicist at Harvard says, “Humans have a long history of messing around in nature with all kinds of unintended consequences. It’s really hubris of us to assume that we know what we are doing and that we can predict what kinds of bad things can happen.”

There are lessons to learn here. CRISPR has the potential to correct damage to DNA caused by human carelessness, pollution, and mismanagement. The rest of the story on gene editing is still to be written. When a Chinese scientist claims to have produced the first gene-edited human babies, there has to be immediate condemnation by the scientific community. Over the years, outstanding scientists have pointed out that science lacks the capacity to determine the use of its discoveries.

We desperately need Christians who are capable scientists using their faith in God to determine those uses. Will CRISPR be used to eliminate genetic diseases, or will it be used by political demagogues to produce pathogens that kill millions of innocent people? The Nobel Peace Prize was started by a man who discovered dynamite and was appalled at the way it was being used to fight wars. That kind of sensitivity is needed in today’s genetic research to write the rest of the story on gene editing.

Another lesson in all of this is that the complexity of the genetic code of life cannot be the result of chance – a blind watchmaker as some have suggested. Wisdom calls out in Proverbs 8, “O you simple ones, understand wisdom … for wisdom is better than rubies; and all things that may be desired are not to be compared to it. I wisdom dwell with prudence and find out knowledge of witty inventions … The Lord possessed me in the beginning of His way, before His works of old … Hear instruction and be wise and refuse it not.”
–John N. Clayton © 2019

Posted on

Human Gene Editing

Human Gene Editing
We have written about human gene editing using the technique known as CRISPR. (Read more about it HERE and HERE.) One of the fears of those who are opposed to uncontrolled use of the CRISPR technique is that it will be used to produce “made to order” babies.

CRISPR could be used to treat a person with a genetic disease, but that is a different scenario from controlling a baby’s athletic skills or eye color. The big problem is that once we apply human gene editing, whatever was changed is passed on to future generations. That includes whatever errors might be made in the process.

He Jiankui, a Chinese scientist, announced in early December 2018, that he had altered the DNA of two embryos to make them resistant to HIV. He then placed them in their mother’s womb resulting in a successful live birth. Marc Thiessen writing in the Washington Post said, “Gene editing is here, and it poses an enormous threat to humanity.” The problem is that there is no way of telling what other characteristics were altered in the process, or what it could lead to. Thiessen says “If science continues down this road, we will cross a moral line from which there may be no return.”

Science cannot determine the use to which its discoveries, such as human gene editing, will be applied. Will CRISPR be used to eliminate diseases that are produced by genetic change? On the other hand, will it become a way for scientists like Jiankui to make large amounts of money by producing made-to-order babies? The belief system of the scientists is what will determine this. An atheist has no reason not to use CRISPR to make a fortune for himself no matter what it does to the human race.

We need Christians who believe God is our Creator. We need scientists and medical practitioners who accept God’s view of humans that we are special, created in His image and the dwelling place of the Holy Spirit. (See 1 Corinthians 3:16.)
–John N. Clayton © 2018

Posted on

Eugenics and CRISPR

Eugenics Logo 1921
In 1927 Supreme Court Justice Oliver Wendell Holmes stated: “Three generations of imbeciles is enough.” He was explaining the court’s support of a Virginia program of involuntary sterilization in a case identified as Buck vs. Bell. The Virginia law and others like it in other states compelled the involuntary sterilization of those people deemed genetically inferior. More than 60,000 people in the United States were sterilized in compliance with the laws the Supreme Court upheld. It was connected to the eugenics movement.

The concept of eugenics goes back at least to the ancient Greeks, but it became a popular movement in Europe and North America in the early twentieth century. In 1931, advocates of eugenics, the movement to improve the genetic quality of the human population, held a “Better Babies” contest in Washington D.C. to popularize the movement. Adolf Hitler used the concept of eugenics to justify his promotion of one superior racial group and to eliminate the inferior groups.

Now in 2018, the concept of using science to produce superior human beings is even more realistic. That is because of a gene-editing tool called CRISPR which geneticists can use to manipulate DNA to control the traits of animals, plants, and people. Dr. Henry Greely of Stanford University says that CRISPR “might one day be used to engineer humans who are more intelligent, beautiful, or athletic.”

It is essential to understand that the potential for good with CRISPR is enormous. It may be possible to cure genetic diseases by using gene editing techniques. It may also be possible to produce useful new food sources. The problem is that gene editing can also be used for evil purposes. Dr. Greely’s statement brings to mind Adolph Hitler’s justification of the extermination of what Hitler considered to be inferior humans.

So what will CRISPR be used for – enormous good, or enormous evil? The answer to that cannot come from science. The religious convictions of those doing the research and those who use the research will decide whether CRISPR does good, or whether it will become a tool of war and ethnic persecution.

Virtually every significant discovery of science can be used for good or evil. Nuclear energy has the potential for enormous good by providing unlimited energy to everyone on the planet. It also has the potential for immense destruction. Dr. Jennifer Doudna at the University of California, Berkeley, is one of the inventors of CRISPR. She has written that she has nightmares “of all the ways in which our hard work might be perverted.”

It is essential that brilliant young Christians become involved in science. They must be involved not only in the research but also in how to use the products of the research.
–John N. Clayton © 2018
Reference: Wall Street Journal August 18/19 2018, page C5.

Posted on

CRISPR and God’s Design

CRISPR and God's Design
The general media and scientific journals have given great attention to something called CRISPR (pronounced like the name of the refrigerator drawer where you stash fresh veggies). CRISPR was first reported in scientific journals and papers in 2012. Now it is being used by scientists all over the world as a method to modify human embryonic stem cells and answer questions about basic biology and development. Here is a sample of what Wikipedia says about it:

“CRISPR is an abbreviation of Clustered Regularly Interspaced Short Palindromic Repeats… A simple version of the CRISPR/Cas system, CRISPR/Cas9, has been modified to edit genomes… CRISPR/Cas genome-editing techniques have many potential applications, including medicine and crop seed enhancement. The use of CRISPR/Cas9-gRNA complex for genome editing was the AAAS’s choice for the breakthrough of the year in 2015. Bioethical concerns have been raised about the prospect of using CRISPR for germline editing.”

That last statement about this technique concerns many people. Are we “playing God” feeling that we can improve on what God has created? Is human genetic engineering going to threaten a catastrophic mistake in the future? Hollywood is already on this with dramas like Netflix’s Luke Cage.

CRISPR exploits something that microbes commonly do in the natural world. Bacteria defend themselves against viruses and other DNA in the environment by having snippets of foreign genetic material as molecular spacers which serve as borders. What scientists are doing is to pick those characteristics that CRISPR can use to eliminate a bad gene and insert a good one in place of it. We are taking something that God has designed into nature and using it to eliminate genetic disorders that may have been caused by human abuse of the environment.

This could be the tool to eliminate nerve damage and give quadriplegics and paraplegics full use of their arms and legs. Trials are already going on to eliminate cystic fibrosis, hemophilia, muscular dystrophy, many forms of cancer, sickle cell anemia, beta thalassemia, and leukemia. This is not replacing God’s original design but rather using some of the tools God created to repair things damaged by time and human abuse. Scientists are harnessing an ancient biological process to edit the code of life. God’s design is what makes this possible and offers great hope for the future of people afflicted with disorders which have not been within our medical reach in the past.
–John N. Clayton © 2018
Reference: Notre Dame Magazine, Spring 2018, pages 22-27.

Posted on

Gene Editing and Better Babies

Gene Editing
A major debate is in the works as scientists experiment with gene editing using CRISPR/Cas9 to fix mutations that cause heart and blood disorders. CRISPR/Cas9 acts as molecular scissors to alter human DNA. The technology is advancing so rapidly that scientists and ethicists are holding conferences to discuss how the technology should be used.

The Hastings Center, which is a bioethics research institute, is sponsoring discussions among experts attempting to give some guidelines for the proper use of gene editing. A panel of ethicists convened by the National Academies of Sciences and Engineering and Medicine has said that gene editing should be used to correct diseases, but not to create characteristics that don’t have to do with health.

Movies like Gattaca have given an awareness of the potential problems with genetic engineering. The Center for Genetics and Society has pointed out that people who are taller and fair-skinned tend to make more money than the general population. The question of whether parents should edit the genes of their children to give those characteristics is an extreme example of how gene editing might be misused.

In the past, we have pointed out the difficulty with any new scientific discovery. We raised the question of whether cloning would be used to produce better crops and save endangered species, or whether it would produce a strain of super-humans endowed with the characteristics of a demented ruler like Hitler–the Boys from Brazil scenario.

From a biblical standpoint, we have to realize that when God created the first humans, they were physically perfect. Many of our diseases and disorders have to a great extent been the product of human greed and foolishness. Pollution, misuse of chemicals and radiation, and a host of recreational drugs have produced a large number of maladies in humans. To be able to go into the cells and edit the DNA to correct genetic disorders may be appropriate, but the potential for misuse is always there.

The moral conviction of the people making these decisions becomes the critical factor. Rather than decry advances in science, we need to join the search to find answers to disease and suffering. Gene editing is the future, let us encourage the best minds in the Christian community to use their God-given talents and abilities to find solutions and direct the use of our knowledge and technology.
–John N. Clayton © 2018
Data from Science News, January 20, 2018, pages 4-5.

Posted on

Genetically Modified Human Embryos

Genetically Modified Human Embryos
Shoukhrat Mitalipov

Chinese scientists have conducted at least three experiments to create genetically modified human embryos. Now, MIT Technology Review reports that a team of scientists in the United States has edited the DNA of human embryos. The experiment was performed at Oregon Health and Science University, a public university in Portland, under the leadership of Shoukhrat Mitalipov. It is apparently the first time this has been done in the United States, and it involved a greater number of embryos than the Chinese experiments.

Mitalipov, who was born in the former Soviet Union and received his Ph.D. in Moscow, came to the U.S. because there was a lack of funding for genetic experimentation in his home country. Since coming to the U.S. he has cloned monkeys and human embryos. This is the first time for editing the DNA of a human embryo.

The scientists used a gene-editing tool called CRISPR, which we have reported on before. The goal of the experiment is supposed to be to find a way to correct genetic defects in humans. The sperm used to fertilize the embryos came from a man with a genetic defect. The embryos were destroyed after a few days because in the United States it is illegal to allow genetically modified human embryos to develop into full-term babies.

In February the U.S. National Academy of Sciences gave support for creating gene-edited babies if the purpose is the elimination of serious genetic diseases. Genetically modified human embryos can develop into gene-modified humans who will pass on the genetic changes to their offspring. This may offer hope for eliminating genetic defects. However, it also has implications for the nightmare scenarios of a science-fiction movie. When humans start to play God by manipulating the DNA of our children, what if they make a disastrous mistake? The United States Intelligence Agency listed CRISPR as a potential “weapon of mass destruction.”

Beyond the implications of Frankenstein-like creatures, there is the aspect of “designer children.” DNA could potentially be edited to select the sex, physical features, and even intelligence of an unborn child. So far that is illegal in the United States, but not in other countries. One of the problems the Chinese experimenters encountered is called “mosaicism,” in which the change to the DNA is not taken on by all of the cells. The implications of a person with multiple DNA codes in different cells is not fully understood. Other CRISPR errors referred to as “off target” effects could result in serious genetic defects. Mitalipov’s team claims to have those problems under control.

The report from this U.S. experiment should be published soon, and it will certainly be in the news. Christians should be concerned about where this is leading. Do humans have the right to play God with our DNA? What could be the result of “off target” mistakes? What about the ethics of creating human embryos for experimentation and then destroying them? Do the possible breakthroughs in the elimination of genetic diseases outweigh the dangers? What about the moral cost to our society as we go down this road?

One thing you can be sure of is that humans will continue to create genetically modified human embryos. If it doesn’t happen in the United States, it will happen in other countries. You can also be sure that there will be some scientists who will do so with less than pure motives. In Mary Shelley’s classic book telling about a scientist’s desire to create a new species, Victor Frankenstein said, “A new species would bless me as its creator and source; many happy and excellent natures would owe their being to me. No father could claim the gratitude of his child so completely as I should deserve theirs.” The power to become a god creating new species of humans can overpower pure motives as it did with Victor Frankenstein. The outcome could be even more tragic than in the novel.

It’s time to consider the many times the Bible tells of the value of every human being and the love God has for us. Many people have become concerned about GMO’s (Genetically Modified Organisms) in food. How much more should we be concerned about Genetically Modified Humans?
–Roland Earnst © 2017